Vernice and Annie, two motherless daughters raised in Honeysuckle, Louisiana, have been best friends and neighbors since earliest childhood, but are fated to live starkly different lives. Raised by a fierce aunt determined to give her a stable home in the wake of her mother’s death, Vernice leaves Atlanta at eighteen for Spelman College, where she joins a sisterhood of powerfully connected Black women and marries into an affluent family. Annie, abandoned by her dissolute mother as a child, and fixated on the idea of finding her and filling the bottomless hole left by her absence, sets off on a journey that will take her into a world of peril and adversity, as well as love and adventure, and culminate in a battle for her life.